Exploring how ovarian cancer cells change metabolism to resist treatment
Understanding Metabolic Reprogramming in Platinum Resistant Ovarian Cancer
This study is looking into why some patients with high-grade serous ovarian cancer stop responding to standard platinum treatments, and it hopes to find new ways to help those patients by understanding how their cancer cells change and adapt.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jesse Brown VA Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10950330 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind platinum resistance in high-grade serous ovarian carcinoma (HGSOC), a common and deadly form of ovarian cancer. It aims to identify new targets and biomarkers that could help in treating patients whose cancer has become resistant to standard platinum-based therapies. By understanding how cancer cells adapt their metabolism, the research seeks to find alternative treatment strategies that could improve patient outcomes. The project involves collaboration among experts in the field to ensure a comprehensive approach to tackling this challenge.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with high-grade serous ovarian carcinoma who have developed resistance to platinum-based chemotherapy.
Not a fit: Patients with early-stage ovarian cancer who have not yet undergone platinum-based treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients with platinum-resistant ovarian cancer, potentially improving survival rates.
How similar studies have performed: Previous research has shown promise in understanding cancer metabolism, but this specific approach to platinum resistance is relatively novel.
Where this research is happening
Chicago, United States
- Jesse Brown VA Medical Center — Chicago, United States (Active)
Researchers
- Principal investigator: Matei, Daniela E — Jesse Brown VA Medical Center
- Study coordinator: Matei, Daniela E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.