Exploring how organ transplants between different age groups affect aging and organ function.
Official title: Understanding Interorgan Communication Through Heterochronic Organ Transplantation
Funded at Brigham and Women's Hospital · NIH-11097230 · Data updated 2026-11-12
This study looks at how organs talk to each other and how their health changes as we age, especially when older organs are given to younger people and the other way around, to help improve transplant success and understand aging better.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $671,950 |
| NIH project number | 5U01AG086168-02 |
| Project ID | NIH-11097230 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who may require organ transplants or are involved in transplant programs.
✕Less likely to help
Patients under the age of 65 or those not requiring organ transplants may not benefit from this research.
What this research studies
This research investigates the communication between organs and how biological age changes with chronological age, particularly through the lens of organ transplantation. By examining cases where older organs are transplanted into younger recipients and vice versa, the study aims to understand how these interactions influence organ health and aging. The research utilizes a combination of clinical data and experimental models to explore the effects of donor and recipient age on organ function and immune response. This could lead to insights on how to improve transplant outcomes and manage aging-related changes in organ function.
Why it matters
Potential benefit: If successful, this research could lead to improved organ transplant outcomes and strategies to mitigate age-related organ decline.
How similar studies have gone: Previous studies have shown promising results in understanding organ aging and immune responses in transplant scenarios, indicating that this approach has potential for significant advancements.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Gladyshev, Vadim N. — Brigham and Women's Hospital
- Study coordinator: Gladyshev, Vadim N.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.