Exploring how oral bacteria from cannabis use affects brain function in people with HIV
Investigating the effect of oral microbiome on cognition in HIV-infected chronic cannabis users
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10886770
This study is looking at how the bacteria in the mouth might affect thinking skills in people with HIV who use cannabis regularly, to see if certain types of bacteria can help or hurt their brain function.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10886770 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between the oral microbiome and cognitive performance in individuals with HIV who are chronic cannabis users. The study aims to understand how specific bacteria, particularly Actinomyces species, may influence cognitive decline or enhancement in this population. By examining both clinical and preclinical models, researchers will assess the impact of cannabis-associated oral bacteria on neurocognitive function. Participants will undergo evaluations to determine the connection between their cannabis use, oral microbiome composition, and cognitive abilities.
Who could benefit from this research
Good fit: Ideal candidates for this research are HIV-infected individuals who are chronic users of cannabis.
Not a fit: Patients who do not have HIV or do not use cannabis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of cognitive issues in HIV-infected individuals who use cannabis.
How similar studies have performed: While the specific focus on the oral microbiome in this context is novel, related research has shown varying effects of cannabis on cognition in HIV-infected populations.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FITTING, SYLVIA — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: FITTING, SYLVIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus