Exploring how opioids and cannabinoids interact in managing pain and reward.

Opioid and cannabinoid interactions in pain and reward

NIH-funded research University of Florida · NIH-10878947

This study is looking at how opioid medications and CBD can work together to help people with chronic pain feel better while also lowering the chances of becoming dependent on opioids, so if you're dealing with pain, this research might offer some helpful insights for safer treatment options.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Florida NIH-funded
Lab location1 site (Gainesville, United States)
Project IDNIH-10878947 on NIH RePORTER

What this research studies

This research investigates the interactions between opioid medications and cannabinoid compounds, such as CBD, in the context of chronic pain management. It aims to understand how these substances can work together to enhance pain relief while reducing the risk of opioid dependency. The study employs a combination of pharmacological assessments, behavioral tests, and neuroimaging techniques to evaluate the effectiveness of these treatments. Patients may benefit from insights into safer pain management strategies that could potentially reduce reliance on opioids.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals experiencing chronic pain who may be using or considering opioid medications.

Not a fit: Patients who do not experience chronic pain or who are not using opioids may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to safer and more effective pain management options for patients suffering from chronic pain.

How similar studies have performed: Previous research has shown promising results in the use of cannabinoids for pain management, suggesting potential for success in this combined approach.

Where this research is happening

Gainesville, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Acquired Immune Deficiency SyndromeAcquired Immunodeficiency Syndrome
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.