Exploring how oncogene enhancers work together using advanced gene editing techniques.
High resolution dissection of oncogene enhancer networks via CRISPR screening and live-cell imaging.
This study is looking at how certain genes, especially the MYC oncogene, are controlled in cancer cells, using advanced techniques to see how different parts of DNA work together, which could help develop new treatments for patients with cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10893556 on NIH RePORTER |
What this research studies
This research investigates the complex networks of regulatory elements that control oncogene expression, focusing on the MYC oncogene. By utilizing CRISPR technology and live-cell imaging, the study aims to dissect how various enhancers interact and influence gene transcription. Patients may benefit from insights gained into the genetic mechanisms of cancer, potentially leading to new therapeutic strategies. The research involves creating a library of guide RNAs to target specific enhancers, allowing for a detailed understanding of their roles in cancer biology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancers associated with oncogene dysregulation, particularly those involving the MYC oncogene.
Not a fit: Patients with cancers not related to oncogene regulation or those with early-stage disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for cancers driven by oncogenes.
How similar studies have performed: Other research using CRISPR technology to explore gene regulation has shown promising results, indicating potential for success in this novel approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Qi, Lei Stanley — Stanford University
- Study coordinator: Qi, Lei Stanley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.