Exploring how nuclear envelope proteins and DNA damage contribute to heart disease
Official title: Understanding the roles of nuclear envelope proteins and DNA damage in cardiomyopathy
Funded at Ut Southwestern Medical Center · NIH-10984733 · Data updated 2026-11-12
This study is looking at how changes in a specific protein called LEMD2 can cause damage to heart cells, which might lead to serious heart problems, and it aims to find new ways to help people with these heart conditions.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | August 15, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $100,480 |
| NIH project number | 1K99HL171887-01A1 |
| Project ID | NIH-10984733 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with genetic mutations affecting nuclear envelope proteins, particularly those diagnosed with cardiomyopathy.
✕Less likely to help
Patients without genetic mutations related to nuclear envelope proteins or those with other forms of heart disease may not benefit from this research.
What this research studies
This research investigates the role of nuclear envelope proteins, specifically LEMD2, in heart diseases known as cardiomyopathies. It focuses on understanding how mutations in these proteins lead to DNA damage in heart muscle cells, which may contribute to the development of severe heart conditions. The study will utilize both human cardiac cells and genetically modified mice to explore the mechanisms linking LEMD2 mutations to heart failure. By characterizing DNA damage and the cellular response to it, the research aims to uncover potential therapeutic targets for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from cardiomyopathies caused by nuclear envelope protein mutations.
How similar studies have gone: Previous studies have shown promising results in understanding the relationship between nuclear envelope proteins and heart disease, indicating that this approach has potential for significant findings.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Caravia, Xurde Menendez — Ut Southwestern Medical Center
- Study coordinator: Caravia, Xurde Menendez
Related research
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-
Global Bromocriptine Trial to Help Postpartum Heart Failure
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.