Exploring how neutrophils affect cancer treatment and side effects
Determining the role of neutrophils in anti-tumor immunity and immune-related adverse events in the context of T cell-based therapies
['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-11027977
This study is looking at how a type of white blood cell called neutrophils can affect cancer treatments that use T cells, helping us find ways to make these therapies work better and reduce any unwanted side effects for patients with solid tumors.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11027977 on ClinicalTrials.gov |
What this research studies
This research investigates the role of neutrophils, a type of white blood cell, in the effectiveness of T cell-based cancer therapies and the immune-related side effects that can occur. The study aims to understand how neutrophils can either help fight tumors or contribute to adverse effects in patients receiving immunotherapy. By analyzing the genetic pathways and factors that influence neutrophil behavior, the research seeks to identify ways to enhance anti-tumor responses while minimizing harmful side effects. This could lead to improved treatment strategies for patients with solid tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with solid tumors who are considering or currently receiving T cell-based immunotherapy.
Not a fit: Patients with non-solid tumors or those not undergoing immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments that reduce side effects for patients undergoing immunotherapy.
How similar studies have performed: Previous research has shown promising results in understanding the role of immune cells in cancer therapy, suggesting that this approach could yield significant insights.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MERGHOUB, TAHA — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: MERGHOUB, TAHA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer immunotherapy