Exploring how neutrophils affect cancer treatment and side effects
Official title: Determining the role of neutrophils in anti-tumor immunity and immune-related adverse events in the context of T cell-based therapies
Funded at Weill Medical Coll of Cornell Univ · NIH-11027977 · Data updated 2026-11-12
This study is looking at how a type of white blood cell called neutrophils can affect cancer treatments that use T cells, helping us find ways to make these therapies work better and reduce any unwanted side effects for patients with solid tumors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 17, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $702,748 |
| NIH project number | 1R01CA297338-01 |
| Project ID | NIH-11027977 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with solid tumors who are considering or currently receiving T cell-based immunotherapy.
✕Less likely to help
Patients with non-solid tumors or those not undergoing immunotherapy may not benefit from this research.
What this research studies
This research investigates the role of neutrophils, a type of white blood cell, in the effectiveness of T cell-based cancer therapies and the immune-related side effects that can occur. The study aims to understand how neutrophils can either help fight tumors or contribute to adverse effects in patients receiving immunotherapy. By analyzing the genetic pathways and factors that influence neutrophil behavior, the research seeks to identify ways to enhance anti-tumor responses while minimizing harmful side effects. This could lead to improved treatment strategies for patients with solid tumors.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments that reduce side effects for patients undergoing immunotherapy.
How similar studies have gone: Previous research has shown promising results in understanding the role of immune cells in cancer therapy, suggesting that this approach could yield significant insights.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Merghoub, Taha — Weill Medical Coll of Cornell Univ
- Study coordinator: Merghoub, Taha
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.