Exploring how Mycobacterium tuberculosis adapts through protein signaling
Official title: Functional exploration of a deep Mycobacterium tuberculosis phosphoproteome
Funded at Seattle Children's Hospital · NIH-11011325 · Data updated 2026-11-12
This study is looking at how the tuberculosis bacteria communicate and adapt to their surroundings, which could help us find new ways to treat the infection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | February 3, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $575,240 |
| NIH project number | 5R01AI170914-03 |
| Project ID | NIH-11011325 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with tuberculosis or those at high risk of developing the disease.
✕Less likely to help
Patients with non-tuberculosis bacterial infections or those without any bacterial infections may not benefit from this research.
What this research studies
This research investigates the complex signaling mechanisms used by Mycobacterium tuberculosis (Mtb) to adapt and survive. By examining the phosphorylation of proteins, which is a key process in bacterial signaling, the study aims to identify how these modifications affect gene expression and bacterial behavior. Using advanced techniques like quantitative mass spectrometry and mutant analysis, researchers will explore the roles of specific kinases in regulating Mtb's response to its environment. This could lead to a better understanding of how tuberculosis bacteria function and how they might be targeted for treatment.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating tuberculosis by targeting the signaling pathways that Mtb uses to survive.
How similar studies have gone: Previous research has shown success in understanding bacterial signaling mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Grundner, Christoph — Seattle Children's Hospital
- Study coordinator: Grundner, Christoph
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.