Exploring how muscle stem cells can regenerate muscle tissue
Official title: Mitochondrial biogenesis and transfer to promote muscle regeneration
Funded at Veterans Affairs Med Ctr San Francisco · NIH-10951493 · Data updated 2026-11-12
This study is looking at how special muscle cells called FAPs can help repair muscles and how certain treatments might make them even better at doing this, which could be helpful for people dealing with muscle weakness from long-term illnesses or injuries.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Affairs Med Ctr San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | October 1, 2023 |
| Project end | September 30, 2027 |
| Funding year | 2025 |
| NIH project number | 5I01BX006098-02 |
| Project ID | NIH-10951493 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing muscle degeneration due to chronic illnesses or musculoskeletal injuries.
✕Less likely to help
Patients with acute muscle injuries or those without any underlying chronic conditions may not benefit from this research.
What this research studies
This research investigates the role of fibroadipoprogenitors (FAPs), which are muscle stem cells, in muscle regeneration. It focuses on how certain stimuli, like B-agonism and intermittent ischemia, can induce a specific fat phenotype that enhances the ability of these cells to regenerate muscle tissue. The study aims to understand the mechanisms behind mitochondrial transfer from FAPs to other cells, which may help improve muscle function in patients suffering from muscle degeneration due to chronic illnesses or injuries.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance muscle regeneration and improve quality of life for patients with muscle degeneration.
How similar studies have gone: Previous research has shown promising results in using similar approaches to enhance muscle regeneration, indicating potential for success in this study.
Where this research is happening
-
Veterans Affairs Med Ctr San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Feeley, Brian — Veterans Affairs Med Ctr San Francisco
- Study coordinator: Feeley, Brian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.