Exploring how multicellular organisms develop and evolve
Using directed evolution to study the origins of multicellular development
['FUNDING_OTHER'] · GEORGIA INSTITUTE OF TECHNOLOGY · NIH-11090868
This study is exploring how simple organisms called 'snowflake yeast' develop into more complex forms with different types of cells and stronger structures, helping us understand how multicellular life evolves and adapts over time.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGIA INSTITUTE OF TECHNOLOGY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-11090868 on ClinicalTrials.gov |
What this research studies
This research investigates the origins of multicellular development by creating a model system called the Multicellularity Long Term Evolution Experiment (MuLTEE). By studying 'snowflake yeast' that have evolved over thousands of generations, the research examines how these organisms develop distinct cell types and enhanced strength through cell-to-cell interactions. The approach combines synthetic biology, mathematical modeling, and biophysical analysis to uncover the mechanisms that drive multicellular evolution and adaptation. This work aims to provide insights into the fundamental processes that govern multicellular life.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions related to cellular behavior and differentiation, particularly those affected by cancers or other diseases involving abnormal cell growth.
Not a fit: Patients with conditions unrelated to cellular development or multicellularity may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of multicellular development, which may inform treatments for diseases related to cell growth and differentiation, such as cancer.
How similar studies have performed: Other research has shown success in understanding multicellular evolution through similar experimental approaches, indicating that this line of inquiry is promising.
Where this research is happening
ATLANTA, UNITED STATES
- GEORGIA INSTITUTE OF TECHNOLOGY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RATCLIFF, WILLIAM CROFT — GEORGIA INSTITUTE OF TECHNOLOGY
- Study coordinator: RATCLIFF, WILLIAM CROFT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers