Exploring how molecular chaperones help break down protein aggregates linked to Alzheimer's disease.
Official title: Understanding the role of molecular chaperone systems in protein aggregate disassembly
Funded at Marquette University · NIH-10974631 · Data updated 2026-11-12
This study is looking at how certain helpers in our cells can break down harmful protein clumps that are linked to Alzheimer's and other brain diseases, with the hope of finding new ways to treat these conditions.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Marquette University NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $459,006 |
| NIH project number | 1R15GM155860-01 |
| Project ID | NIH-10974631 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related neurodegenerative disorders.
✕Less likely to help
Patients with non-neurodegenerative conditions or those without protein aggregation-related diseases may not benefit from this research.
What this research studies
This research investigates the role of molecular chaperones in managing protein aggregates that are associated with neurodegenerative diseases like Alzheimer's. The team will study how these chaperones disassemble harmful protein structures, which can become irreversible with age and stress. By understanding the mechanisms behind this process, the research aims to uncover new therapeutic strategies for treating conditions related to protein aggregation. Patients may benefit from insights that could lead to innovative treatments for Alzheimer's and similar diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively treat or slow the progression of Alzheimer's disease.
How similar studies have gone: Other research has shown promise in understanding the role of molecular chaperones in protein aggregation, suggesting that this approach could yield significant advancements.
Where this research is happening
-
Marquette University
Milwaukee, United States Active
Researchers
- Principal investigator: Manogaran, Anita L. — Marquette University
- Study coordinator: Manogaran, Anita L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.