Exploring how mitochondrial RNA affects aging and cell health
Official title: Investigating the role of cytosolic mitochondrial double-stranded RNA in cellular senescence and aging
Funded at Mayo Clinic Rochester · NIH-11076815 · Data updated 2026-11-12
This study is looking at how a specific type of RNA in our cells might affect aging and cause inflammation, with the goal of finding ways to help people age healthier and feel better as they get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 15, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $571,621 |
| NIH project number | 5R01AG082708-03 |
| Project ID | NIH-11076815 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related health issues or conditions associated with cellular senescence.
✕Less likely to help
Patients who are younger and do not have age-related diseases or conditions may not benefit from this research.
What this research studies
This research investigates the role of mitochondrial double-stranded RNA in the aging process and its connection to cellular senescence, which is when cells lose their ability to divide and function properly. The study aims to understand how this RNA can trigger inflammation and contribute to age-related diseases. By examining the relationship between mitochondrial dysfunction and the inflammatory response in senescent cells, researchers hope to identify new strategies to target these cells and promote healthier aging. This could lead to interventions that improve healthspan by reducing the negative effects of aging.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance healthy aging and reduce age-related diseases.
How similar studies have gone: Other research has shown promising results in targeting cellular senescence to improve health outcomes, suggesting that this approach may be effective.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Passos, Joao — Mayo Clinic Rochester
- Study coordinator: Passos, Joao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.