Exploring how mitochondrial RNA affects aging and cell health
Investigating the role of cytosolic mitochondrial double-stranded RNA in cellular senescence and aging
This study is looking at how a specific type of RNA in our cells might affect aging and cause inflammation, with the goal of finding ways to help people age healthier and feel better as they get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11076815 on NIH RePORTER |
What this research studies
This research investigates the role of mitochondrial double-stranded RNA in the aging process and its connection to cellular senescence, which is when cells lose their ability to divide and function properly. The study aims to understand how this RNA can trigger inflammation and contribute to age-related diseases. By examining the relationship between mitochondrial dysfunction and the inflammatory response in senescent cells, researchers hope to identify new strategies to target these cells and promote healthier aging. This could lead to interventions that improve healthspan by reducing the negative effects of aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related health issues or conditions associated with cellular senescence.
Not a fit: Patients who are younger and do not have age-related diseases or conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance healthy aging and reduce age-related diseases.
How similar studies have performed: Other research has shown promising results in targeting cellular senescence to improve health outcomes, suggesting that this approach may be effective.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Passos, Joao — Mayo Clinic Rochester
- Study coordinator: Passos, Joao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.