Exploring how mitochondrial dysfunction and chronic stress contribute to breast cancer disparities among different racial groups.
Mitochondrial dysfunction and chronic stress intersect as mechanisms driving breast cancer racial disparities
This study is looking at how stress and problems with tiny parts of our cells called mitochondria might lead to more aggressive breast cancer in African American women, and it hopes to find ways to help those at higher risk.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-10673729 on NIH RePORTER |
What this research studies
This research investigates the intersection of mitochondrial dysfunction and chronic stress as factors that may contribute to the higher rates of aggressive breast cancer in African American women. It aims to understand how physiological stress, measured through allostatic load, affects breast cancer risk and outcomes, particularly focusing on mitochondrial DNA changes. By analyzing biological samples and patient data, the study seeks to uncover the underlying mechanisms that lead to disparities in breast cancer severity and mortality rates. The findings could help identify targeted interventions for at-risk populations.
Who could benefit from this research
Good fit: Ideal candidates for this research include African American women diagnosed with breast cancer, especially those with aggressive subtypes.
Not a fit: Patients who do not have breast cancer or those from racial groups not significantly affected by the disparities being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for breast cancer, particularly for African American women who are disproportionately affected.
How similar studies have performed: Previous studies have indicated that mitochondrial dysfunction and stress-related factors are linked to cancer outcomes, suggesting that this research builds on established findings rather than exploring a completely novel approach.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Shock, Lisa Sale — Virginia Commonwealth University
- Study coordinator: Shock, Lisa Sale
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.