Exploring how mitochondrial dysfunction affects vascular health and hypertension in Black Americans
Mitochondria Dysfunction as a Contributor to Racial Disparities in Vascular Health and Hypertension
This study is looking at how problems with tiny parts of our cells called mitochondria might lead to higher blood pressure and heart issues in Black Americans, and it aims to find ways to improve heart health by checking blood samples for clues about how these cell parts are working.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Auburn University at Auburn NIH-funded |
| Lab location | 1 site (Auburn, UNITED STATES) |
| Project ID | NIH-10515262 on NIH RePORTER |
What this research studies
This research investigates the role of mitochondrial dysfunction in contributing to higher rates of hypertension and cardiovascular diseases among Black Americans. It focuses on understanding how biological factors, particularly mitochondrial health, influence vascular function and oxidative stress in this population. The study will analyze blood samples to assess mitochondrial respiration and oxidative stress levels, aiming to identify potential interventions that could improve vascular health. By including a diverse participant group, the research seeks to address existing disparities in cardiovascular health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for participation include Black adults aged 21 and older who are experiencing hypertension or related cardiovascular issues.
Not a fit: Patients who are not of Black descent or those without hypertension or cardiovascular concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that improve vascular health and reduce hypertension rates among Black Americans.
How similar studies have performed: Previous research has shown promising results in improving vascular function through mitochondrial-targeted antioxidants, although few studies have focused specifically on Black adults.
Where this research is happening
Auburn, UNITED STATES
- Auburn University at Auburn — Auburn, United States (Active)
Researchers
- Principal investigator: Kavazis, Andreas N — Auburn University at Auburn
- Study coordinator: Kavazis, Andreas N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.