Exploring how mitochondrial DNA affects viral diseases and type 2 diabetes
Official title: Defining the Contribution of Mitochondrial DNA to Viral Infectious Diseases, Type 2 Diabetes, and their Interactions
Funded at Veterans Health Administration · NIH-11098420 · Data updated 2026-11-12
This study is looking at how tiny parts of our cells called mitochondrial DNA might affect the way viral infections and type 2 diabetes develop, especially in Veterans, to help find better treatments for these conditions and their links, including how they relate to COVID-19.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01BX006162-03 |
| Project ID | NIH-11098420 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include Veterans who have been diagnosed with type 2 diabetes or viral infectious diseases.
✕Less likely to help
Patients without a diagnosis of type 2 diabetes or viral infectious diseases may not benefit from this research.
What this research studies
This research investigates the role of mitochondrial DNA in the development and interaction of viral infectious diseases and type 2 diabetes, particularly in Veterans. The team will analyze genetic data from the Million Veteran Program to identify how variations in mitochondrial DNA may influence these conditions and their relationship with each other. By understanding these connections, the research aims to uncover mechanisms that could lead to better treatment strategies for affected individuals. The study will focus on the immune responses and metabolic changes associated with these diseases, especially in the context of COVID-19.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with type 2 diabetes and viral infectious diseases.
How similar studies have gone: Previous research has shown promising results in understanding the genetic factors influencing metabolic and infectious diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Veterans Health Administration
Nashville, United States Active
Researchers
- Principal investigator: Hulgan, Todd M — Veterans Health Administration
- Study coordinator: Hulgan, Todd M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.