Exploring how methionine metabolism can help treat cancer
Understanding methionine metabolism and its therapeutic potential in cancer
This study is looking at how changing the amount of methionine, an important nutrient, in your diet might help slow down cancer growth and improve how well chemotherapy works, using real cancer samples from patients to see what happens.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10817923 on NIH RePORTER |
What this research studies
This research investigates the role of methionine, an essential amino acid, in cancer metabolism and its potential as a therapeutic target. By manipulating dietary methionine levels, the study aims to understand how this affects tumor growth and response to chemotherapy. The approach includes using patient-derived cancer models to assess the impact of methionine restriction on tumor progression and treatment efficacy. The research seeks to uncover the molecular mechanisms behind these effects, potentially leading to new dietary strategies for cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with specific types of cancers, particularly those driven by RAS mutations, such as colorectal cancer.
Not a fit: Patients with cancers that do not rely on methionine metabolism or those who are not eligible for dietary interventions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative dietary interventions that enhance cancer treatment outcomes.
How similar studies have performed: Previous research has shown promising results with dietary interventions in cancer models, indicating potential for success in this novel approach.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Gao, Xia — Baylor College of Medicine
- Study coordinator: Gao, Xia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.