Exploring how metals and proteins work together in biological processes
Redox Cofactor Diversity in Enzymatic Superfamilies
['FUNDING_OTHER'] · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · NIH-10836980
This study is looking at how metals like iron work with proteins in our bodies to help carry out important chemical reactions, which could lead to new treatments for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10836980 on ClinicalTrials.gov |
What this research studies
This research investigates the unique ways that metals, particularly iron, interact with proteins to facilitate various chemical transformations in living organisms. By studying metalloproteins and metalloenzymes, the project aims to understand the structure-function relationships within enzyme superfamilies, focusing on how these interactions can lead to diverse biochemical reactions. The research involves examining the properties of redox-active cofactors, such as iron-sulfur clusters and heme groups, to uncover their roles in enzymatic activity. Patients may benefit from insights gained into these fundamental biological processes, which could inform the development of new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with metabolic disorders or conditions affecting enzyme function.
Not a fit: Patients with conditions unrelated to enzymatic processes or metal ion metabolism may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to advancements in understanding and treating conditions related to enzyme deficiencies or dysfunctions.
How similar studies have performed: Previous research has shown success in understanding metalloproteins and their roles in biological systems, indicating that this approach is grounded in established scientific principles.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ELLIOTT, SEAN J — BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
- Study coordinator: ELLIOTT, SEAN J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.