Exploring how metal ions affect the CRISPR-Cas9 gene editing system
Investigating the metal-dependent function, allostery and inhibition of CRISPR-Cas9
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA RIVERSIDE · NIH-11055349
This study is looking at how different metal ions affect the CRISPR-Cas9 gene-editing tool, which could help scientists make it work better for fixing genetic diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA RIVERSIDE (nih funded) |
| Locations | 1 site (RIVERSIDE, UNITED STATES) |
| Trial ID | NIH-11055349 on ClinicalTrials.gov |
What this research studies
This research investigates the CRISPR-Cas9 system, a groundbreaking tool for gene editing, focusing on how different metal ions influence its function. The study aims to understand the mechanisms of DNA cleavage, the role of allosteric modulation in engineered Cas9 variants, and how natural proteins can inhibit this system. By using advanced molecular dynamics simulations, researchers will explore these complex interactions to enhance the precision and control of CRISPR technology. This work could lead to improved strategies for correcting genetic diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders that could potentially be treated through advanced gene editing techniques.
Not a fit: Patients with conditions that are not amenable to gene editing or those who do not have genetic mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and precise gene editing therapies for various genetic diseases.
How similar studies have performed: Previous research has shown promising results in enhancing CRISPR technology, indicating that this approach could lead to significant advancements in gene editing.
Where this research is happening
RIVERSIDE, UNITED STATES
- UNIVERSITY OF CALIFORNIA RIVERSIDE — RIVERSIDE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PALERMO, GIULIA — UNIVERSITY OF CALIFORNIA RIVERSIDE
- Study coordinator: PALERMO, GIULIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.