NIH-funded research Fellowship grant

Exploring how mental imagery affects perceptual abnormalities in individuals at risk for psychosis

Official title: The Role of Mental Imagery in Perceptual Abnormality Formation in Individuals at Clinical High-Risk for Psychosis

Funded at Northwestern University · NIH-11066140 · Data updated 2026-11-12

This study is looking at how the way you imagine things in your mind might affect the way you see and experience the world, especially for people who are at risk of developing psychosis, to help us understand their experiences better.

Quick facts

Grant typeFellowship grant
Study typeNIH-funded research
Funding institutionNorthwestern University
NIH-funded
Lab location1 site (Chicago, UNITED STATES)
Project startNovember 1, 2024
Project endOctober 31, 2027
Funding year2024
Award (this year)$76,756
NIH project number1F32MH139246-01
Project IDNIH-11066140 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are individuals identified as being at clinical high-risk for psychosis who experience perceptual abnormalities.

Less likely to help

Patients who do not have any risk factors for psychosis or do not experience perceptual abnormalities may not benefit from this research.

What this research studies

This research investigates how mental imagery influences the formation of perceptual abnormalities, such as hallucinations, in individuals identified as being at clinical high-risk for psychosis. By examining the relationship between mental imagery and predictive coding, the study aims to understand how prior knowledge and expectations shape perceptual experiences. Participants will be assessed to determine how vivid mental imagery may impact their perceptions and beliefs, potentially leading to a better understanding of their experiences. The study will involve a sample of individuals who experience these perceptual abnormalities and those who do not, providing insights into the underlying mechanisms at play.

Why it matters

Potential benefit: If successful, this research could lead to improved interventions for individuals at risk for psychosis by enhancing our understanding of how mental imagery contributes to their perceptual experiences.

How similar studies have gone: While the role of mental imagery in perceptual abnormalities has not been extensively studied, related research in non-psychiatric populations suggests promising avenues for understanding these mechanisms.

Where this research is happening

  • Northwestern University
    Chicago, United States
    Active

Researchers

  • Principal investigator: Pratt, Danielle N — Northwestern University
  • Study coordinator: Pratt, Danielle N

Related research

Other NIH-funded projects on the same topics.

  • Psychosis in diverse settings across the world

    This project studies how psychotic disorders show up and respond to treatment in adults with diverse backgrounds, including populations in Africa, the Caribbean, and other Global South settings.

    NIH research Suny Downstate Medical Center · Brooklyn, United States · NIH-11592428

  • Psychosis in Diverse Settings: Understanding Symptoms and Treatment Across Global South

    A human-facing study will look at how psychotic disorders present and respond to treatment in adults from Africa, the Caribbean, and other Global South settings, using genetic and clinical data.

    NIH research Suny Downstate Medical Center · Brooklyn, United States · NIH-11592427

  • A new online brain-scan-style tool to spot early psychosis risk

    A new online-based set of tasks and a computer model aims to identify people at high risk for developing psychosis earlier and more accurately.

    NIH research Northwestern University · Chicago, United States · NIH-11590585

  • Genetic clues for early-onset psychosis in Latino youth

    This project looks at the genes of young people with early-onset psychosis and compares them with similar youths without psychosis to find genetic factors that contribute to the illness.

    NIH research Boston Children's Hospital · Boston, United States · NIH-11554752

  • Biomarkers to tailor rehab for Veterans with schizophrenia

    A clinician-scientist is developing a brain-based biomarker to guide personalized rehabilitation for Veterans with schizophrenia.

    NIH research VA San Diego Healthcare System · San Diego, United States · NIH-11552825

  • Computational analysis of facial expression in early psychosis

    Aims to develop computer-based measures of facial expression in people at risk for or with schizophrenia to help track symptoms and guide future trials.

    NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11539126

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.