Exploring how memory CD8 T cells function and persist in the body
Understanding the functional agility of effector memory CD8 T cells
This study is looking at special immune cells called memory CD8 T cells, which help your body fight off infections and stay protected after vaccinations, to see how a particular group of these cells, known as long-lived effector cells, work over time and how they respond to infections, especially when there's inflammation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10866601 on NIH RePORTER |
What this research studies
This research investigates the behavior of memory CD8 T cells, which are crucial for the immune response after infections or vaccinations. It focuses on a specific subset of these cells known as long-lived effector cells (LLECs) that maintain their functionality over time. The study aims to understand how these cells respond to infections, their unique characteristics, and how they are influenced by their environment, particularly during inflammation. By using advanced techniques like RNA sequencing and innovative mouse models, the research seeks to uncover the mechanisms that allow these T cells to effectively protect the body from pathogens.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions that affect their immune response, such as chronic infections or immunodeficiencies.
Not a fit: Patients with stable immune function and no history of infections may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing immune responses in patients, potentially benefiting those with weakened immune systems.
How similar studies have performed: Previous research has shown promising results in understanding T cell behavior, suggesting that this approach could yield valuable insights.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Hamilton Hart, Sara Elizabeth — University of Minnesota
- Study coordinator: Hamilton Hart, Sara Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.