Exploring how membrane proteins are regulated by their environment
Understanding membrane proteins’ allosteric modulation with cryo-EM
This study is looking at how certain proteins in our cells, which help control heart and muscle function, work and how they can be influenced by different substances, with the goal of finding new ways to treat heart and muscle problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10842901 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that control how transmembrane receptors function and how their signaling is modulated. Using advanced techniques like cryo-electron microscopy, the team examines how different ligands affect the behavior of important receptors involved in heart and muscle function. The study focuses on understanding the role of calcium signaling and how small molecules and proteins influence receptor activity, which could lead to new treatments for cardiac and muscle disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cardiac diseases or muscle disorders who may benefit from new therapeutic approaches targeting calcium signaling.
Not a fit: Patients with conditions unrelated to calcium signaling or transmembrane receptor function may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies for patients suffering from cardiac and muscle disorders.
How similar studies have performed: Other research has shown success in understanding receptor modulation and signaling pathways, indicating that this approach has potential for significant advancements.
Where this research is happening
New York, United States
- New York University — New York, United States (Active)
Researchers
- Principal investigator: Des Georges, Amedee — New York University
- Study coordinator: Des Georges, Amedee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.