Exploring how mechanical load affects the regeneration of mammalian digits and limbs
Official title: Understanding the Role of Mechanical Load in Endogenous and Induced Mammalian Digit Regeneration
Funded at Arizona State University-Tempe Campus · NIH-11018741 · Data updated 2026-11-12
This study is looking at how the pressure and movement on healing limbs can help them grow back better after an amputation, using mice to find ways to improve treatments for people who have lost a limb.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project start | June 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $485,782 |
| NIH project number | 1R01HD116825-01 |
| Project ID | NIH-11018741 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced limb loss or amputation and are seeking innovative treatment options.
✕Less likely to help
Patients with conditions unrelated to limb loss or those who have not undergone amputation may not benefit from this research.
What this research studies
This research investigates the role of mechanical load in the regeneration of mammalian digits, particularly focusing on how it influences the healing process after limb amputation. By using mouse models, the study aims to understand the mechanisms behind tissue regeneration and how these insights can lead to improved therapies for humans with limb loss. The research will explore the potential of using specific proteins, like BMP2, to enhance regeneration in non-regenerative wounds, ultimately aiming to translate these findings into effective treatments for amputated limbs. Patients may benefit from new therapeutic strategies that could restore function and improve quality of life after amputation.
Why it matters
Potential benefit: If successful, this research could lead to groundbreaking therapies that enhance limb regeneration and improve outcomes for patients with amputations.
How similar studies have gone: Previous research has shown promising results in using mechanical load and specific proteins to enhance regeneration in animal models, indicating potential for success in human applications.
Where this research is happening
-
Arizona State University-Tempe Campus
Tempe, United States Active
Researchers
- Principal investigator: Dolan, Connor Patrick — Arizona State University-Tempe Campus
- Study coordinator: Dolan, Connor Patrick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.