Exploring how MARCH9 helps fight HIV-1 infection
Official title: Understanding the Antiviral Mechanism of MARCH9
Funded at State University of New York at Buffalo · NIH-11009319 · Data updated 2026-11-12
This study is looking at how a protein called MARCH9 can help lower the ability of HIV-1 to infect cells, which could lead to new and better treatments for people living with HIV.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | July 10, 2024 |
| Project end | July 9, 2027 |
| Funding year | 2024 |
| Award (this year) | $36,070 |
| NIH project number | 1F31AI186661-01 |
| Project ID | NIH-11009319 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV-1 who are seeking new treatment options.
✕Less likely to help
Patients who are not infected with HIV-1 or those who are already responding well to existing antiretroviral therapies may not benefit from this research.
What this research studies
This research investigates the role of a protein called MARCH9 in reducing the infectivity of HIV-1, the virus responsible for AIDS. By studying how MARCH9 interacts with immune cells and affects the production of viral proteins, the research aims to uncover new therapeutic targets that could lead to more effective treatments for HIV. The approach involves detailed laboratory experiments to understand the mechanisms by which MARCH9 operates without harming the immune cells. This could provide insights into developing novel antiviral strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for HIV-1 that are more effective and have fewer side effects than current therapies.
How similar studies have gone: Other research has shown promise in targeting host proteins to combat HIV, suggesting that this approach could yield valuable insights.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: D'angelo, Mary Rose — State University of New York at Buffalo
- Study coordinator: D'angelo, Mary Rose
Related research
Other NIH-funded projects on the same topics.
-
Improving population health by studying reproductive health and development.
This study is looking at how different factors, like the environment and genetics, affect the health of pregnant women and people of reproductive age, with the goal of improving pregnancy outcomes and the health of children as they grow up.
-
How noise and hearing loss affect the first step of hearing in the brain
This NIH grant studies how noise and conductive hearing loss change the intimate connections between auditory nerves and brain cells, which could influence how we hear in noisy environments.
-
Programmable hydrogels to protect transplanted human OPCs in demyelinating disease
Aims to improve survival and integration of transplanted human oligodendrocyte precursor cells by using specially designed hydrogels to reduce cell death during delivery in demyelinating diseases like multiple sclerosis.
-
How a mouth bacterium might fuel gum disease and heart risk
A small study will look at how a bacterium in the mouth that makes a reactive chemical (methylglyoxal) could drive gum inflammation and changes in the mouth’s bacteria, possibly linking to heart disease.
-
New dual-acting treatments against tough Klebsiella pneumoniae infections
A new funding opportunity aims to develop therapies that both fight and disarm the dangerous Klebsiella pneumoniae bacteria, especially strains that resist many drugs, to help patients with serious infections.
-
Muscle health and aging in postmenopausal women
This NIH grant supports a study in older, postmenopausal women to understand how insulin and blood sugar relate to muscle loss over time and whether this differs by race/ethnicity.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.