Exploring how lung stem cells are affected by genetic regulation in congenital lung disease
Official title: Understanding the impact of targeting the epigenetic regulation of lung stem cells in congenital lung disease
Funded at Massachusetts General Hospital · NIH-10726411 · Data updated 2026-11-12
This study is looking at how certain genes might affect lung development in babies with congenital lung diseases like Congenital Diaphragmatic Hernia (CDH), and it aims to find ways to help improve lung function for those little ones.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $167,000 |
| NIH project number | 1R03HD112717-01 |
| Project ID | NIH-10726411 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns diagnosed with Congenital Diaphragmatic Hernia or other congenital lung diseases.
✕Less likely to help
Patients with congenital lung diseases unrelated to the genetic factors being studied may not benefit from this research.
What this research studies
This research investigates the role of specific genes in the development of congenital lung diseases, particularly focusing on Congenital Diaphragmatic Hernia (CDH). By analyzing lung stem cells from both affected and healthy newborns, the study aims to understand how the loss of certain genetic functions impacts lung development. The researchers will utilize advanced genomic techniques to identify key genes involved in lung growth and assess their effects on stem cell behavior. This could lead to insights into potential therapies for improving lung function in affected infants.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve lung development and health outcomes for infants with congenital lung diseases.
How similar studies have gone: Previous research has shown promise in understanding genetic factors in congenital diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Rowbotham, Samuel Philip — Massachusetts General Hospital
- Study coordinator: Rowbotham, Samuel Philip
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.