Exploring how lung bacteria affect inflammation in COPD for people with HIV
Official title: Investigating the role of altered lung microbiome in fueling Th17 mediated airway inflammation in COPD among HIV-infected individual
Funded at Makerere University College of Health Sciences · NIH-10653253 · Data updated 2026-11-12
This study is looking at how the bacteria in the lungs might affect inflammation in people with both HIV and COPD, and it hopes to find new ways to help manage lung problems for those living with these conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Makerere University College of Health Sciences NIH-funded |
| Lab location | 1 site (Kampala, Uganda) |
| Project start | July 1, 2022 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $123,120 |
| NIH project number | 5R21TW012354-02 |
| Project ID | NIH-10653253 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults living with HIV who are experiencing symptoms of COPD.
✕Less likely to help
Patients who do not have HIV or COPD may not benefit from this research.
What this research studies
This research investigates the connection between the lung microbiome and airway inflammation in individuals living with HIV who have chronic obstructive pulmonary disease (COPD). By analyzing sputum samples from participants in Uganda, the study aims to identify specific bacteria that may contribute to inflammation and immune responses in the lungs. The researchers will focus on understanding how these microbial communities interact with the immune system, particularly the Th17 response, to drive chronic lung issues in this population. The findings could provide insights into new treatment strategies for managing COPD in HIV-infected individuals.
Why it matters
Potential benefit: If successful, this research could lead to improved management and treatment options for COPD in people living with HIV.
How similar studies have gone: Previous research has indicated that the lung microbiome plays a role in respiratory diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Makerere University College of Health Sciences
Kampala, Uganda Active
Researchers
- Principal investigator: Kayongo, Alex — Makerere University College of Health Sciences
- Study coordinator: Kayongo, Alex
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.