Exploring how life stress affects health through genetic changes
The Add Health Epigenome Resource: Life course stressors and epigenomic modifications in adulthood
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10865306
This study looks at how stress we experience throughout our lives can affect our genes and health later on, helping us understand why some people face more health challenges as adults.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10865306 on ClinicalTrials.gov |
What this research studies
This research investigates how psychosocial stressors experienced throughout life can lead to changes in the epigenome, which may contribute to health disparities in adulthood. By utilizing data from the National Longitudinal Study of Adolescent to Adult Health, the study aims to connect detailed information about life stress with genetic markers that indicate health outcomes. The goal is to understand the biological pathways that link stress to mental health issues and other health conditions, providing insights into how early life experiences can shape health in adulthood.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have experienced varying levels of psychosocial stress throughout their lives.
Not a fit: Patients who have not experienced significant psychosocial stressors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and interventions for health disparities related to stress and mental health.
How similar studies have performed: Previous research has shown promising results in linking psychosocial stress to health outcomes through epigenetic changes, indicating that this approach has potential for success.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AIELLO, ALLISON E — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: AIELLO, ALLISON E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.