Exploring how ketones affect heart function in patients with heart failure
Dissecting the Ketone Metabolic Axis in Heart Failure with Reduced Ejection Fraction
This study is looking at how ketone therapy might help people with heart failure feel better and exercise more easily by improving their heart and muscle function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10896384 on NIH RePORTER |
What this research studies
This research investigates the effects of ketone therapy on patients with heart failure with reduced ejection fraction (HFrEF). It aims to understand how ketones can improve heart function and exercise capacity, which are critical for enhancing the quality of life in these patients. The study will involve administering ketone esters to participants in a controlled trial to observe their impact on heart and muscle function. By analyzing various metabolic and physiological responses, the research seeks to uncover new treatment avenues for heart failure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with heart failure with reduced ejection fraction (HFrEF).
Not a fit: Patients with heart failure who do not have reduced ejection fraction or those with other significant comorbidities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance exercise capacity and quality of life for patients with heart failure.
How similar studies have performed: Previous research has shown promising results with ketone therapy in improving heart function, suggesting that this approach may be beneficial.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Selvaraj, Senthil — Duke University
- Study coordinator: Selvaraj, Senthil
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.