Exploring how jumping genes affect health and disease in vertebrates
Understanding the regulation and impact of transposable elements in Vertebrate health and disease
This study is looking at how special pieces of DNA, called "jumping genes," affect health and diseases like cancer and brain disorders, and it's for anyone interested in understanding how our genes work and how they can sometimes go wrong.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10879033 on NIH RePORTER |
What this research studies
This research investigates the role of transposable elements, often referred to as 'jumping genes', in regulating genomic functions that impact vertebrate health and disease. By examining how these elements are controlled throughout life in various tissues, the study aims to uncover their influence on conditions such as cancer and neurodegeneration. The research employs advanced techniques, including big data analysis and machine learning, to analyze genomic patterns and their variations between sexes. This work seeks to provide insights into the mechanisms that maintain cellular health and how disruptions can lead to disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a genetic predisposition to diseases influenced by genomic regulation, particularly those over 21 years old.
Not a fit: Patients with conditions unrelated to genomic regulation or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating diseases linked to genomic regulation, potentially improving health outcomes for patients.
How similar studies have performed: While the study of transposable elements is gaining attention, this specific approach to understanding their regulation in relation to health and disease is relatively novel and has not been extensively tested.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Benayoun, Berenice Anath — University of Southern California
- Study coordinator: Benayoun, Berenice Anath
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.