Exploring how inflammation affects feelings of pleasure and motivation
Probing the Nexus: Unraveling Neuroinflammation's Link to Anhedonia
['FUNDING_R03'] · WASHINGTON UNIVERSITY · NIH-11034860
This study is looking at how inflammation in the brain might affect the ability to feel pleasure, especially in different age groups, and it's for anyone interested in understanding more about how these factors relate to feelings of joy and motivation.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11034860 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between neuroinflammation and anhedonia, which is the inability to feel pleasure. By analyzing data from large datasets like the UK Biobank and the Adolescent Brain Cognitive Development study, the researchers aim to understand how inflammation in the brain may influence symptoms of anhedonia, particularly in different age groups. The study employs advanced imaging techniques to observe changes in the brain related to inflammation and reward processing. Patients may be asked to participate in assessments that track their emotional and motivational responses over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who experience symptoms of anhedonia, particularly those with psychiatric disorders.
Not a fit: Patients who do not experience anhedonia or related psychiatric symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for individuals experiencing anhedonia, improving their quality of life.
How similar studies have performed: Previous studies have shown promising results in understanding the role of inflammation in mental health, suggesting that this approach may yield valuable insights.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHANG, WEI — WASHINGTON UNIVERSITY
- Study coordinator: ZHANG, WEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.