Exploring how inflammation affects dopamine signaling in the brain
Using Human iPSC Models to Determine the Mechanism of Inflammation-Induced Disruption of Dopamine Neurotransmission
This study is looking at how inflammation in the body affects the brain's dopamine system, which is important for mood and pleasure, to help us understand why some people with inflammation might feel depressed, and it could lead to better treatments for those experiencing these symptoms.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10707196 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which inflammation disrupts dopamine neurotransmission, particularly focusing on how inflammatory cytokines like IL-6 impact dopamine vesicles in the brain. Using innovative human induced pluripotent stem cell (hiPSC) technology, the study aims to understand the cellular and molecular changes that occur in dopamine neurons during inflammation. By examining these processes, the research seeks to shed light on the relationship between inflammation and symptoms of depression, such as anhedonia, which is a significant challenge for many patients. The findings could lead to new insights into how to better treat depression linked to inflammatory responses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing depression, especially those with symptoms related to inflammation.
Not a fit: Patients with depression not linked to inflammatory processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for depression, particularly for patients whose symptoms are exacerbated by inflammation.
How similar studies have performed: Previous studies have shown that inflammation can significantly affect dopamine signaling, indicating that this research builds on established findings while exploring new mechanisms.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Wen, Zhexing — Emory University
- Study coordinator: Wen, Zhexing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.