Exploring how infections may influence breast cancer development in women with BRCA1 mutations
Investigating the relationship between the systemic response to infection and tumor initiation and progression in Brca1 breast cancer
This study is looking at how urinary tract infections might affect breast cancer development in women with BRCA1 mutations, hoping to find new ways to detect and prevent the disease early.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-11094006 on NIH RePORTER |
What this research studies
This research investigates the connection between infections, specifically urinary tract infections (UTIs), and the development of breast cancer in women with BRCA1 mutations. The study aims to identify how these infections may alter mammary tissue and immune responses, potentially leading to faster tumor growth. Using advanced techniques like single-cell RNA sequencing and flow cytometry, researchers will analyze changes in mammary epithelial cells and the surrounding tissue environment. The goal is to uncover new biomarkers for early detection and prevention of breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are women with BRCA1 mutations who have experienced urinary tract infections.
Not a fit: Patients without BRCA1 mutations or those who have not had urinary tract infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection and prevention strategies for breast cancer in women with BRCA1 mutations.
How similar studies have performed: While the specific relationship between UTIs and breast cancer in BRCA1 mutation carriers is novel, similar research has shown that infections can influence cancer progression in other contexts.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Lewis, Steven Macauley — State University New York Stony Brook
- Study coordinator: Lewis, Steven Macauley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.