Exploring how infections may influence Alzheimer's disease and testing vaccines for prevention.
Leveraging population-based human data to uncover mechanisms connecting Alzheimer's disease and common infections and facilitate vaccines repurposing for AD prevention
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-10884167
This study is looking at how infections might be connected to Alzheimer's disease in older adults, especially if a weaker immune system makes them more prone to infections, and it hopes to find out if certain vaccines could help prevent Alzheimer's.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10884167 on ClinicalTrials.gov |
What this research studies
This research investigates the potential link between infections and Alzheimer's disease (AD), focusing on how compromised immunity might increase vulnerability to infections that could contribute to AD. By analyzing population-based data, the study aims to understand the impact of infectious diseases and vaccinations on AD-related traits in older adults. The researchers will utilize advanced techniques that mimic clinical trials to assess these relationships, potentially identifying existing vaccines that could be repurposed for AD prevention.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above, particularly those with a history of infections or vaccinations.
Not a fit: Patients under 65 years of age or those without any history of infections or vaccinations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing Alzheimer's disease through the use of existing vaccines.
How similar studies have performed: Other research has suggested that vaccines may have unexpected benefits for conditions like Alzheimer's, indicating a promising area of exploration.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OUKRAINTSEVA, SVETLANA V. — DUKE UNIVERSITY
- Study coordinator: OUKRAINTSEVA, SVETLANA V.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.