Exploring how immune system issues affect memory decline in older adults
Investigating the Contribution of Peripheral versus Central Nervous System Immune Dysfunction to Cognitive Aging
This study is looking at how issues with the immune system outside the brain might affect memory and thinking as we get older, and it's for older adults who want to understand more about how their health and memory are connected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10534200 on NIH RePORTER |
What this research studies
This research investigates the role of immune dysfunction in cognitive aging, particularly focusing on how problems in the peripheral immune system may contribute to memory decline, independent of the central nervous system. The study will utilize advanced techniques to measure immune markers in blood and cerebrospinal fluid, as well as analyze extracellular vesicles that carry immune signals. By tracking these markers over time, the research aims to uncover the relationship between peripheral and central immune responses and their impact on cognitive health in older adults. This approach could lead to better understanding and potential interventions for cognitive decline associated with aging and Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those showing early signs of cognitive decline or at risk for Alzheimer's disease.
Not a fit: Patients who are younger or do not have any cognitive decline or risk factors for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or mitigating cognitive decline in older adults.
How similar studies have performed: Previous research has indicated that immune dysfunction is linked to cognitive decline, suggesting that this approach may yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Bettcher, Brianne Magouirk — University of Colorado Denver
- Study coordinator: Bettcher, Brianne Magouirk
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.