Exploring how immune pathways affect cardiometabolic risks across generations
Official title: Inter-Generational Cardiometabolic Risk: Explore Underlying Immune Pathways
Funded at Johns Hopkins University · NIH-10950432 · Data updated 2026-11-12
This study is looking at how a mother's health during pregnancy, especially if she has infections or inflammation, can affect her child's chances of developing health issues like obesity, diabetes, and heart problems later in life, and it involves checking blood samples and health information from families to learn more about this connection.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 17, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $245,625 |
| NIH project number | 1R21HD116039-01 |
| Project ID | NIH-10950432 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include pregnant women and their children, particularly those from low-income and minority backgrounds who are at higher risk for cardiometabolic conditions.
✕Less likely to help
Patients who are not pregnant or do not have children may not receive direct benefits from this research.
What this research studies
This research investigates the connection between maternal health and the cardiometabolic risks faced by their children, particularly focusing on how infections and inflammation during pregnancy may influence these risks. By examining the immune responses in both mothers and their offspring, the study aims to uncover the biological mechanisms that contribute to obesity, type 2 diabetes, and cardiovascular diseases. The research will involve analyzing blood samples and health data from families to better understand these intergenerational links and their implications for future health.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing obesity and related diseases in children and future generations.
How similar studies have gone: Previous research has shown promising results in understanding the links between maternal health and child outcomes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Wang, Guoying — Johns Hopkins University
- Study coordinator: Wang, Guoying
Related research
Other NIH-funded projects on the same topics.
-
Targeting hidden brain injuries in iTTP to improve long-term brain health
A researcher aims to find out how silent brain injuries in people with immune thrombotic thrombocytopenic purpura (iTTP) happen, how they affect thinking and stroke risk, and how to prevent them.
-
Accelerated flap coverage for severe leg injuries: earlier reconstruction vs standard timing
This study tests whether doing early flap coverage after a severe leg injury lowers infection risk and improves healing for patients with open wounds and bone injury.
-
Placebo-controlled shunting for iNPH: does the surgery help with walking and balance?
A doctor-led trial at Johns Hopkins will test whether a shunt surgery improves walking and balance in older adults with idiopathic normal pressure hydrocephalus.
-
Omalizumab for COPD patients with allergen sensitization and exposure
A multicenter trial will test whether adding omalizumab helps people with COPD who are allergic to common indoor allergens and are exposed to them.
-
Johns Hopkins Total Worker Health Center focusing on mental health
A nationwide center at Johns Hopkins is working to improve mental health and well-being among workers by studying workplace health strategies and translating findings into practical tools.
-
Role of fat droplets in liver fat and inflammatory signals in NAFLD
A study at Johns Hopkins will explore how fat droplets in the liver influence molecules that drive inflammation and progression of non-alcoholic fatty liver disease (NAFLD) in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.