Exploring how immune pathways affect cardiometabolic risks across generations
Inter-Generational Cardiometabolic Risk: Explore Underlying Immune Pathways
This study is looking at how a mother's health during pregnancy, especially if she has infections or inflammation, can affect her child's chances of developing health issues like obesity, diabetes, and heart problems later in life, and it involves checking blood samples and health information from families to learn more about this connection.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10950432 on NIH RePORTER |
What this research studies
This research investigates the connection between maternal health and the cardiometabolic risks faced by their children, particularly focusing on how infections and inflammation during pregnancy may influence these risks. By examining the immune responses in both mothers and their offspring, the study aims to uncover the biological mechanisms that contribute to obesity, type 2 diabetes, and cardiovascular diseases. The research will involve analyzing blood samples and health data from families to better understand these intergenerational links and their implications for future health.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant women and their children, particularly those from low-income and minority backgrounds who are at higher risk for cardiometabolic conditions.
Not a fit: Patients who are not pregnant or do not have children may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing obesity and related diseases in children and future generations.
How similar studies have performed: Previous research has shown promising results in understanding the links between maternal health and child outcomes, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Wang, Guoying — Johns Hopkins University
- Study coordinator: Wang, Guoying
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.