Exploring how immune cells affect cancer treatment outcomes
Understanding the role and clinical potential of dominant immune suppressive myeloid-cell responses in human cancer
This study is looking at how certain immune cells affect lung and colorectal cancers to find new ways to help patients get better treatments, especially those who haven't responded well to current options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10897339 on NIH RePORTER |
What this research studies
This research investigates the role of immune suppressive myeloid cells in lung and colorectal cancers, which are among the deadliest forms of cancer. The team aims to identify new biomarkers that can help select patients for immunotherapy and uncover additional therapeutic targets beyond existing treatments. By studying the IL-8/CXCR1/CXCR2 pathway, the research seeks to understand how immune responses can be manipulated to improve treatment efficacy. Patients may benefit from insights that could lead to more effective therapies for those who currently do not respond to standard treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with lung or colorectal cancer who are seeking new treatment options.
Not a fit: Patients with cancers other than lung or colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with lung and colorectal cancers, particularly those who are resistant to current therapies.
How similar studies have performed: Previous research has shown promise in targeting immune pathways for cancer treatment, suggesting that this approach could lead to significant advancements.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Schalper, Kurt a — Yale University
- Study coordinator: Schalper, Kurt a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.