Exploring how human cells respond to various small molecules and gene changes
The LINCS DCIC Engagement Plan with the CFDE
This study is looking at how human cells react to various small molecules and genetic changes to help researchers better understand diseases and improve treatments, making it useful for anyone interested in new medicines and their effects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10128125 on NIH RePORTER |
What this research studies
This research investigates the responses of human cells to different small molecules and genetic modifications by utilizing a vast collection of data from the Library of Integrated Network-based Cellular Signatures (LINCS). The project aims to profile over 50 types of perturbed human cells using advanced techniques such as transcriptomics and proteomics, generating over 2 million cellular signatures. These signatures will serve as a valuable resource for understanding disease mechanisms, drug repurposing, and predicting drug side effects, ultimately enhancing biomedical research and therapeutic development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that could benefit from new drug discoveries or insights into disease mechanisms.
Not a fit: Patients with conditions that are not addressed by the small molecules or genetic modifications being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of diseases and more effective drug therapies for patients.
How similar studies have performed: Other research initiatives utilizing large-scale cellular data have shown promise in advancing drug discovery and understanding disease biology, indicating a strong potential for success in this approach.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Ma'ayan, Avi — Icahn School of Medicine at Mount Sinai
- Study coordinator: Ma'ayan, Avi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.