Exploring how HIV-1 avoids the immune system
Understanding Immune Evasion by HIV-1 Repliclones
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11089519
This study is looking at how certain HIV-1 cells manage to hide from the immune system and stick around even when people are on effective treatment, with the goal of finding better ways to target and get rid of these stubborn cells.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11089519 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which HIV-1 repliclones evade the immune system, particularly focusing on how these cells can persist despite effective antiretroviral therapy (ART). The study aims to understand the role of transcriptional silence, dysfunctional immune responses, and mutations in the virus that allow it to escape immune clearance. By examining these factors, the research seeks to uncover new insights into the HIV reservoir and its behavior during treatment. This could lead to improved strategies for targeting and eliminating these persistent viral cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy and may have detectable low-level viremia.
Not a fit: Patients who are not living with HIV or those who have not been on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for HIV, potentially reducing the viral reservoir and improving long-term health outcomes for patients.
How similar studies have performed: Previous research has shown promising results in understanding HIV reservoirs and immune evasion, indicating that this approach builds on established findings in the field.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HALVAS, ELIAS K. — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: HALVAS, ELIAS K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus