Exploring how histone H3 helps manage copper in cells
Understanding the function of histone H3 as an oxidoreductase enzyme
This study is looking at how a protein called histone H3 helps cells use copper, which is important for keeping cells healthy, especially in relation to cancer, and it aims to understand how changes in this protein might affect copper levels in our bodies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10749905 on NIH RePORTER |
What this research studies
This research investigates the role of histone H3 as an enzyme that helps convert copper ions into a usable form for cells. By understanding how histone H3 interacts with copper, the study aims to uncover its importance in cellular processes, particularly in relation to cancer and cellular function. The researchers will use various techniques to analyze how changes in histone H3 affect copper levels and related cellular activities. This could provide insights into how cells maintain copper homeostasis, which is crucial for their health and function.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with cancers that may be influenced by copper metabolism.
Not a fit: Patients with conditions unrelated to copper metabolism or those not diagnosed with cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing copper levels in cancer cells, potentially improving treatment outcomes.
How similar studies have performed: While the specific role of histone H3 as an oxidoreductase is novel, similar studies have shown that understanding metal ion homeostasis can significantly impact cancer treatment.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Kurdistani, Siavash — University of California Los Angeles
- Study coordinator: Kurdistani, Siavash
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.