Exploring how high doses of THC affect behavior and brain function in adolescents
Determining the role of tripartite cell populations in THC-Induced behavioral phenotypes
['FUNDING_CAREER'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11055325
This study looks at how high doses of THC, the main ingredient in cannabis, affect the behavior and brain function of young animals, helping us understand how using cannabis during teenage years might influence stress and addiction risks later in life.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11055325 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of high doses of THC, the active ingredient in cannabis, on adolescent behavior and brain function. By studying animal models, the researchers aim to understand how THC exposure during adolescence influences stress responses and addiction risk later in life. The study focuses on changes in specific brain regions, particularly the amygdala, and how these changes relate to psychiatric conditions. The findings could provide insights into the neurobiological mechanisms underlying addiction and mental health issues associated with cannabis use.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are adolescents aged 12-20 who are experiencing or at risk for addiction or related psychiatric conditions.
Not a fit: Patients who are not adolescents or who do not use cannabis may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for addiction and mental health issues in adolescents who use cannabis.
How similar studies have performed: Previous research has shown that high doses of THC can affect brain function and behavior, indicating that this area of study is both relevant and important.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FERLAND, JACQUELINE-MARIE — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: FERLAND, JACQUELINE-MARIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: addictive disorder