Exploring how gut bacteria metabolites influence immune responses
Official title: Chemoproteomic discovery and functional analysis microbiota bile acid-protein targets in host immunity
Funded at Scripps Research Institute, the · NIH-11068923 · Data updated 2026-11-12
This study is looking at how substances made by gut bacteria can influence our immune system, and it's for anyone interested in finding new ways to treat infections and cancer in both people and animals.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | December 9, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $891,678 |
| NIH project number | 1R01AI182439-01A1 |
| Project ID | NIH-11068923 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with immune-related conditions or those at risk for infections and cancer.
✕Less likely to help
Patients who do not have immune-related conditions or are not affected by gut microbiota may not benefit from this research.
What this research studies
This research investigates how key metabolites produced by gut bacteria, such as bile acids, affect the immune system. By using advanced techniques in chemical biology and proteomics, the study aims to identify the specific proteins these metabolites interact with in mammalian cells. The research will involve both laboratory experiments and mouse models to understand the mechanisms of action of these metabolites on host immunity. The ultimate goal is to uncover new therapeutic targets that could lead to improved treatments for infections and cancer in both animals and humans.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance immune responses against infections and cancer.
How similar studies have gone: Previous research has shown promise in understanding the role of gut microbiota in immune modulation, suggesting potential for success in this area.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Hang, Howard C — Scripps Research Institute, the
- Study coordinator: Hang, Howard C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.