Exploring how gut bacteria influence immune system development
Official title: Dissecting microbiota-driven lymphangiogenesis in immune health and disease
Funded at University of Pittsburgh at Pittsburgh · NIH-10907807 · Data updated 2026-11-12
This study is looking at how certain bacteria in our gut, especially Helicobacter hepaticus, can influence our immune system and help us understand diseases like cancer and autoimmune disorders, so we can learn more about keeping our immune health in check.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $467,159 |
| NIH project number | 5DP2AI177967-02 |
| Project ID | NIH-10907807 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with immune-based diseases such as cancer or autoimmune disorders.
✕Less likely to help
Patients without immune-related conditions or those not affected by gut microbiota may not benefit from this research.
What this research studies
This research investigates the relationship between gut microbiota and immune responses in both health and disease. It focuses on how specific gut bacteria, particularly Helicobacter hepaticus, can promote the development of lymphatic structures that are crucial for immune function. The study employs advanced techniques to analyze the signals and cell types involved in this process, aiming to uncover the mechanisms by which gut bacteria affect immune health. By understanding these interactions, the research seeks to provide insights into conditions like cancer and autoimmune diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing immune-related diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of gut microbiota in immune health, suggesting that this approach could yield significant insights.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Overacre-Delgoffe, Abigail E — University of Pittsburgh at Pittsburgh
- Study coordinator: Overacre-Delgoffe, Abigail E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.