Exploring how gut bacteria affect PTSD after brain injuries
Official title: Investigating the role of gut-derived extracellular vesicles in PTSD following TBI
Funded at Henry Ford Health + Michigan State University Health Sciences · NIH-10883161 · Data updated 2026-11-12
This study is looking at how tiny particles from the gut might affect the development of PTSD in people who have had a traumatic brain injury, with the hope of finding new ways to help those dealing with these challenges.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry Ford Health + Michigan State University Health Sciences NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | September 5, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $485,152 |
| NIH project number | 1R01NS133347-01A1 |
| Project ID | NIH-10883161 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced traumatic brain injury and are showing symptoms of PTSD or other psychiatric disorders.
✕Less likely to help
Patients without a history of traumatic brain injury or those not experiencing PTSD or related psychiatric symptoms may not benefit from this research.
What this research studies
This research investigates the connection between gut-derived extracellular vesicles and the development of posttraumatic stress disorder (PTSD) in individuals who have experienced traumatic brain injury (TBI). By examining how gut microbiota and their byproducts influence serotonin levels and inflammation, the study aims to uncover the mechanisms that link TBI to PTSD and other psychiatric disorders. The approach includes analyzing samples from patients and animal models to identify potential therapeutic targets. The ultimate goal is to improve understanding and treatment options for those suffering from these conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for PTSD and related psychiatric disorders in patients with a history of traumatic brain injury.
How similar studies have gone: Previous research has indicated a strong correlation between gut microbiota and mental health disorders, suggesting that this approach may yield valuable insights and potential breakthroughs.
Where this research is happening
-
Henry Ford Health + Michigan State University Health Sciences
East Lansing, United States Active
Researchers
- Principal investigator: Liu, Xianshuang — Henry Ford Health + Michigan State University Health Sciences
- Study coordinator: Liu, Xianshuang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.