Exploring how gut bacteria affect infections in leukemia treatment
Novel analysis of association between microbiome and treatment infection in AML
This study is looking at how the bacteria in the gut might affect infections in people with Acute Myeloid Leukemia (AML) during chemotherapy, with the hope of finding better ways to manage treatments and keep patients healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10680521 on NIH RePORTER |
What this research studies
This research investigates the relationship between the gut microbiome and treatment-related infections in patients with Acute Myeloid Leukemia (AML). By analyzing complex data from microbiome sequencing, the study aims to develop new statistical methods to better understand how gut bacteria influence patient responses to chemotherapy. Patients may benefit from insights that could lead to improved treatment strategies and infection management during their care. The research focuses on the unique challenges posed by the high-dimensional data generated from microbiome studies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Acute Myeloid Leukemia who are undergoing chemotherapy treatment.
Not a fit: Patients with other types of leukemia or those not receiving chemotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment protocols for AML patients by minimizing infection risks associated with chemotherapy.
How similar studies have performed: Previous research has shown promising results in understanding the microbiome's role in various diseases, suggesting potential for success in this novel approach.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Hu, Jianhua — Columbia University Health Sciences
- Study coordinator: Hu, Jianhua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.