Exploring how gut bacteria affect brain health in Alzheimer's disease
Understanding the “Microbiome-gut-brain axis” in Alzheimer’s disease and its Role in Cognitive Decline
This study is looking at how the bacteria in our gut might affect memory and thinking skills in older adults with Alzheimer's and mild cognitive issues, and it involves 260 participants who will be observed over time to see if certain gut bacteria are linked to changes in their brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11003497 on NIH RePORTER |
What this research studies
This research investigates the connection between the gut microbiome and cognitive decline in Alzheimer's disease. It involves a cohort of 260 older adults, including those diagnosed with Alzheimer's and mild cognitive impairment, who are being monitored over time. Researchers collect clinical data and biological samples to analyze the microbiome's role in inflammation and cognitive function. The study aims to identify specific microbiome characteristics that correlate with cognitive decline and inflammation levels.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults diagnosed with Alzheimer's disease or mild cognitive impairment.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cognitive decline in Alzheimer's patients by targeting the gut microbiome.
How similar studies have performed: Previous research has shown promising results in understanding the microbiome's impact on brain health, suggesting that this approach could yield valuable insights.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Haran, John Patrick — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Haran, John Patrick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.