Exploring how gut and nasal bacteria interact with genetics to influence asthma in children
Official title: Novel Integrative Analysis of Microbiome and Host Genetics in Childhood Asthma Research
Funded at University of Wisconsin-Madison · NIH-11208037 · Data updated 2026-11-12
This study is looking at how the bacteria in kids' noses and guts, along with their genes, might affect their chances of having asthma, with the goal of finding new ways to help manage and prevent asthma in children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | June 17, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $597,904 |
| NIH project number | 1R01AI192972-01 |
| Project ID | NIH-11208037 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who are at risk for or currently have asthma.
✕Less likely to help
Patients outside the age range of 0-11 years or those without asthma or asthma risk factors may not benefit from this research.
What this research studies
This research investigates the relationship between the microbiome (the collection of bacteria in the body) and host genetics in children with asthma. By analyzing large datasets of infant nasal and gut microbiomes alongside genetic information, the study aims to identify how these factors contribute to asthma risk. The researchers will develop new statistical methods to better understand these interactions and their potential role in asthma prevention and control. This approach could lead to innovative strategies for managing childhood asthma based on individual microbiome profiles.
Why it matters
Potential benefit: If successful, this research could lead to personalized prevention and treatment strategies for childhood asthma based on microbiome and genetic profiles.
How similar studies have gone: Previous research has shown promising results in understanding the role of the microbiome in asthma, making this approach both innovative and grounded in prior success.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Chen, Guanhua — University of Wisconsin-Madison
- Study coordinator: Chen, Guanhua
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.