Exploring how grit can help prevent cognitive decline in aging and Alzheimer's disease
Grit against cognitive decline in aging and preclinical Alzheimer Disease
This study is looking at how having determination and staying motivated can help older adults, especially those at risk for Alzheimer's, keep their thinking skills strong even when certain brain changes are present.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10884017 on NIH RePORTER |
What this research studies
This research investigates the relationship between grit, or perseverance, and cognitive resilience in older adults, particularly those at risk for Alzheimer's disease. It aims to understand how motivational factors can help some individuals maintain their cognitive abilities despite the presence of amyloid, a marker associated with Alzheimer's. By examining brain structures linked to motivation, the study seeks to uncover the neural mechanisms that support this resilience. Participants may engage in tasks designed to assess their grit and cognitive function over time.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults who are cognitively normal but have amyloid accumulation, indicating a higher risk for developing Alzheimer's disease.
Not a fit: Patients with advanced Alzheimer's disease or significant cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preserving cognitive function in aging individuals and those at risk for Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of motivational factors in cognitive resilience, suggesting that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Touroutoglou, Alexandra — Massachusetts General Hospital
- Study coordinator: Touroutoglou, Alexandra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.