Exploring how glycine receptors work in brain signaling
Understanding higher-order glycine receptor assemblies in neurotransmission
['FUNDING_OTHER'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11090351
This study is looking at how special proteins called glycine receptors work in the brain, which is important for sending messages between nerve cells, and it aims to help us understand their role in conditions like autism.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11090351 on ClinicalTrials.gov |
What this research studies
This research investigates the structure and function of glycine receptors, which are crucial for transmitting electrical signals between nerve cells. By using advanced techniques like cryo-electron microscopy, the team aims to uncover how these receptors cluster at synapses, which are the communication points between neurons. Understanding these receptor assemblies could provide insights into their role in various neurological conditions, particularly autism spectrum disorders. The research will also develop new methods to analyze these receptor structures in detail.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder, particularly those over 21 years old.
Not a fit: Patients with neurological conditions unrelated to glycine receptor dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for conditions like autism spectrum disorder.
How similar studies have performed: Previous research has shown success in characterizing other neurotransmitter receptors, suggesting potential for breakthroughs in understanding glycine receptors as well.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, WEIWEI — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: WANG, WEIWEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: autism spectral disorder, autism spectrum disorder, Autistic Disorder, autistic spectrum disorder