Exploring how genetics, immune response, and gut microbes affect Crohn's disease recurrence after surgery

Who could benefit from this research

What this research studies

This research investigates the complex interactions between a patient's genetics, their immune response, and gut microbes to understand why Crohn's disease often recurs after surgical treatment. By analyzing samples collected from patients who have undergone ileocolic resection, the study aims to identify biomarkers and mechanisms that contribute to disease recurrence. Utilizing advanced techniques like high-throughput omics and antibody profiling, the research seeks to uncover insights that could lead to more effective prevention and treatment strategies for Crohn's disease. Patients involved in this study will contribute to a biobank that supports ongoing research into this condition.

Why it matters

Where this research is happening

• Sinai Health System
  Toronto, Canada Active

Researchers

• Principal investigator: Lee, Sun-Ho — Sinai Health System
• Study coordinator: Lee, Sun-Ho

Related research

Other NIH-funded projects on the same topics.

• Why Crohn's sometimes returns after surgery: genes, immunity, and gut bugs

  This project looks at how a person's genes, immune responses, and gut microbes are linked to Crohn's disease coming back after bowel surgery for people who had ileocolic resection.

  NIH research Sinai Health System · Toronto, Canada · NIH-11330272

• Investigating the role of gut bacteria and genetics in Crohn's disease complications.

  This study is looking at how the bacteria in your gut, your genes, and fat around your intestines can affect scarring in Crohn's disease, and it aims to create a way to spot patients who might be at higher risk for complications or flare-ups after surgery, with the hope of finding better treatments to help manage this

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-10769731

• Site-specific gene-microbial interactions in children with Crohn’s disease

  A child-focused study explores how genes and gut microbes interact in very young children with Crohn’s disease to understand why the disease starts and how it might be treated.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11451806

• Ultrasound markers to measure Crohn’s disease activity

  A Mayo Clinic team is testing new 3D ultrasound methods to reliably track inflammation and scarring in Crohn’s disease using safe, affordable imaging that could replace more costly scans.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11445984

• Understanding abnormal sugar building blocks in Crohn’s disease to guide smarter therapies

  This project looks at how a specific genetic variation affects how Crohn’s disease works and whether targeting that pathway could lead to new treatments.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11405064

• AI and single-cell tests to predict Crohn's disease course in children

  This project uses artificial intelligence plus single-cell and other molecular data to predict which children and teens with Crohn's disease will have mild versus severe or treatment‑resistant disease.

  NIH research Duke University · Durham, United States · NIH-11404078

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.