Exploring how genetics, immune response, and gut microbes affect Crohn's disease recurrence after surgery
Understanding the Interaction between Host Genetics, Immune response, and Gut Microbes in Post-operative Recurrence of Crohn's disease
['FUNDING_R01'] · SINAI HEALTH SYSTEM · NIH-11026380
This study is looking at how your genes, immune system, and gut bacteria work together to understand why Crohn's disease can come back after surgery, and by participating, you'll help researchers find better ways to prevent and treat the disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SINAI HEALTH SYSTEM (nih funded) |
| Locations | 1 site (TORONTO, CANADA) |
| Trial ID | NIH-11026380 on ClinicalTrials.gov |
What this research studies
This research investigates the complex interactions between a patient's genetics, their immune response, and gut microbes to understand why Crohn's disease often recurs after surgical treatment. By analyzing samples collected from patients who have undergone ileocolic resection, the study aims to identify biomarkers and mechanisms that contribute to disease recurrence. Utilizing advanced techniques like high-throughput omics and antibody profiling, the research seeks to uncover insights that could lead to more effective prevention and treatment strategies for Crohn's disease. Patients involved in this study will contribute to a biobank that supports ongoing research into this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have undergone ileocolic resection due to Crohn's disease and are at risk of disease recurrence.
Not a fit: Patients who have not had surgery for Crohn's disease or those with other forms of inflammatory bowel disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing the recurrence of Crohn's disease after surgery, enhancing patient outcomes.
How similar studies have performed: Previous research has shown promise in understanding Crohn's disease recurrence through genetic and microbial analysis, indicating that this approach could yield valuable insights.
Where this research is happening
TORONTO, CANADA
- SINAI HEALTH SYSTEM — TORONTO, CANADA (ACTIVE)
Researchers
- Principal investigator: LEE, SUN-HO — SINAI HEALTH SYSTEM
- Study coordinator: LEE, SUN-HO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.