Exploring how genetic variations affect gene regulation
Function-based exploration of genetic variation at genome-scale
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-10878938
This study is looking at how certain genetic changes, especially in parts of our DNA that don't code for proteins, might affect our health and risk for diseases, using a special tool called CRISPR to see how these changes influence gene activity, which could help create more personalized treatments for patients like you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10878938 on ClinicalTrials.gov |
What this research studies
This research investigates the functional relevance of genetic variants, particularly those located in non-coding regions of the genome, which are often linked to disease risk. By using advanced CRISPR/Cas9 technology, the study aims to systematically perturb these genetic variants and observe their effects on gene regulation at a large scale. Patients may benefit from insights gained about how specific genetic variations influence health and disease, potentially leading to more personalized treatment options. The research employs a method called targeted Perturb-seq to analyze the regulatory networks of genes across an entire human chromosome.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic variations linked to specific diseases or phenotypic traits.
Not a fit: Patients without identifiable genetic variations or those with conditions unrelated to genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of genetic factors influencing diseases, paving the way for more targeted and effective therapies.
How similar studies have performed: Previous research using CRISPR technology for functional genomics has shown promising results, indicating that this approach could yield significant insights into gene regulation.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STEINMETZ, LARS M — STANFORD UNIVERSITY
- Study coordinator: STEINMETZ, LARS M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.