Exploring how genetic variants in the TRIO gene affect brain function and development
Official title: Identification and characterization of chemical probes of TRIO GEF1 activity
Funded at Yale University · NIH-10986996 · Data updated 2026-11-12
This study is looking at how a gene called TRIO might be linked to conditions like autism and schizophrenia, and it aims to find new ways to help manage these conditions by discovering small molecules that can change how TRIO works.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | December 1, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $557,907 |
| NIH project number | 5R01MH132685-02 |
| Project ID | NIH-10986996 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with neurodevelopmental disorders such as autism or schizophrenia, particularly those with known TRIO gene variants.
✕Less likely to help
Patients without neurodevelopmental disorders or those not carrying TRIO gene variants may not benefit from this research.
What this research studies
This research investigates the role of the TRIO gene in neurodevelopmental disorders such as autism and schizophrenia. By identifying how specific genetic variants influence TRIO's activity, the study aims to uncover the underlying mechanisms that affect neuronal development. The researchers will use advanced screening techniques to find small molecules that can either enhance or inhibit TRIO's function, potentially leading to new therapeutic strategies. This work could provide insights into how to better manage or treat conditions associated with abnormal brain function.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurodevelopmental disorders, improving outcomes for affected individuals.
How similar studies have gone: Other research has shown promise in targeting genetic variants for therapeutic purposes, suggesting that this approach could be effective.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Koleske, Anthony J — Yale University
- Study coordinator: Koleske, Anthony J
Related research
Other NIH-funded projects on the same topics.
-
Aging Well with HIV: Alcohol, Risk Reduction, and Education Center (AWAR3E)
A center at Yale is exploring how aging with HIV interacts with alcohol use to create inflammation and frailty, with the goal of finding biomarkers and potential treatments.
-
Community Health Worker–Led Hypertension Prevention and Control in Nepal
A community health worker–driven approach in Nepal aims to prevent and control high blood pressure among adults by bringing education and care directly to communities and homes.
-
Community health worker-led hypertension prevention and control in Nepal
A community health worker–led program in Nepal aims to help adults prevent and better control high blood pressure through home visits, education, and ongoing support.
-
Adapting a mobile health tool to boost HIV outcomes for older adults with HIV in Ukraine
A mobile health platform called PositiveLinks would be adapted for older adults with HIV in Ukraine to help them stay engaged in care and improve treatment success.
-
Behavioral and neural links between spoken language sounds and written words in young children
This grant studies how young children learn from listening and reading to improve literacy, by looking at how sound patterns transfer to written language.
-
Understanding how autoimmunity causes myasthenia gravis
This project looks at why the immune system attacks the nerve-muscle connection in myasthenia gravis and how different patient groups are affected.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.