Exploring how genetic variants in the TRIO gene affect brain function and development
Identification and characterization of chemical probes of TRIO GEF1 activity
This study is looking at how a gene called TRIO might be linked to conditions like autism and schizophrenia, and it aims to find new ways to help manage these conditions by discovering small molecules that can change how TRIO works.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10986996 on NIH RePORTER |
What this research studies
This research investigates the role of the TRIO gene in neurodevelopmental disorders such as autism and schizophrenia. By identifying how specific genetic variants influence TRIO's activity, the study aims to uncover the underlying mechanisms that affect neuronal development. The researchers will use advanced screening techniques to find small molecules that can either enhance or inhibit TRIO's function, potentially leading to new therapeutic strategies. This work could provide insights into how to better manage or treat conditions associated with abnormal brain function.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with neurodevelopmental disorders such as autism or schizophrenia, particularly those with known TRIO gene variants.
Not a fit: Patients without neurodevelopmental disorders or those not carrying TRIO gene variants may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurodevelopmental disorders, improving outcomes for affected individuals.
How similar studies have performed: Other research has shown promise in targeting genetic variants for therapeutic purposes, suggesting that this approach could be effective.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Koleske, Anthony J — Yale University
- Study coordinator: Koleske, Anthony J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.